A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

BACKGROUND AND PURPOSE: The rabbit isolated Langendorff heart model (SCREENIT) was used to investigate the proarrhythmic potential of a range of marketed drugs or drugs intended for market. These data were used to validate the SCREENIT model against clinical outcomes. EXPERIMENTAL APPROACH: Fifty-fi...

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Bibliographic Details
Main Authors: Lawrence, C L, Bridgland-Taylor, M H, Pollard, C E, Hammond, T G, Valentin, J-P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014697/
https://ncbi.nlm.nih.gov/pubmed/17031389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706894
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