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Effect of alosetron on theophylline pharmacokinetics

AIMS: To examine the potential for alosetron to alter the pharmacokinetics of theophylline by inhibiting its metabolism, as suggested by in vitro and in vivo effects on CYP1A2 activity. METHODS: Ten healthy female volunteers received theophylline 200 mg twice daily alone for 8 days and with alosetro...

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Bibliografske podrobnosti
Main Authors: Koch, K M, Ricci, B M, Hedayetullah, N S, Jewell, D, Kersey, K E
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014605/
https://ncbi.nlm.nih.gov/pubmed/11736869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01477.x
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