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Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers

AIMS: To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. METHODS: Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects...

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Detalhes bibliográficos
Main Authors: Simon, T, Becquemont, L, Hamon, B, Nouyrigat, E, Chodjania, Y, Poirier, J M, Funck-Brentano, C, Jaillon, P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014598/
https://ncbi.nlm.nih.gov/pubmed/11736870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01494.x
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