Influence of cirrhosis on lamotrigine pharmacokinetics

AIMS: Lamotrigine, an antiepileptic drug, is cleared from the systemic circulation mainly by glucuronidation. The possibility of changes in the pharmacokinetics of lamotrigine in plasma owing to hepatic dysfunction has been evaluated. METHODS: Thirty-six subjects, including 24 patients with various...

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Hlavní autoři: Marcellin, P, de Bony, F, Garret, C, Altman, C, Boige, V, Castelnau, C, Laurent-Puig, P, Trinchet, J C, Rolan, P, Chen, C, Mamet, J P, Bidault, R
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2001
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014475/
https://ncbi.nlm.nih.gov/pubmed/11421997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01389.x
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