Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis

AIMS: To investigate the effects of age and disease states on the expression and activity of intestinal CYP3A4 in a paediatric population. METHODS: Duodenal biopsies and surgical sections were collected from 104 paediatric patients (age range 2 weeks to 17 years) and from 11 foetuses. An S9 fraction...

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Detalhes bibliográficos
Main Authors: Johnson, Trevor N, Tanner, M Stuart, Taylor, Christopher J, Tucker, Geoffrey T
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014473/
https://ncbi.nlm.nih.gov/pubmed/11422003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01370.x
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