Pharmacokinetics and tolerability of intravenous infusion of adenosine (SUNY4001) in healthy volunteers

AIMS: To examine the tolerability and disposition of i.v. adenosine (SUNY4001) in healthy male Japanese volunteers. METHODS: SUNY4001 was infused i.v. for 6 min at 0 (placebo), 60, 100, 120 and 140 µg kg(−1) min(−1) in a dose-escalating manner in 30 healthy subjects. Adenosine and its metabolites we...

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Autors principals: Uematsu, Toshihiko, Kozawa, Osamu, Matsuno, Hiroyuki, Niwa, Masayuki, Yoshikoshi, Hirofumi, Oh-uchi, Mikio, Kohno, Ken-ichi, Nagashima, Satoru, Kanamaru, Mitsutaka
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2000
Matèries:
Short Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014395/
https://ncbi.nlm.nih.gov/pubmed/10930971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00214.x
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