Fluoxetine inhibits the metabolism of tolterodine—pharmacokinetic implications and proposed clinical relevance

AIMS: To investigate the change in disposition of tolterodine during coadministration of the potent cytochrome P450 2D6 (CYP2D6) inhibitor fluoxetine. METHODS: Thirteen patients received tolterodine l-tartrate 2 mg twice daily for 2.5 days, followed by fluoxetine 20 mg once daily for 3 weeks and the...

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Hlavní autoři: Brynne, N, Svanström, C, Åberg-Wistedt, A, Hallén, B, Bertilsson, L
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 1999
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014382/
https://ncbi.nlm.nih.gov/pubmed/10583026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00051.x
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