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Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects

AIMS: The prevalence of hyperuricaemia and gout increases with age as does the incidence of adverse effects to allopurinol, the major uric acid lowering drug. The present study was performed to compare the disposition and effects of allopurinol and its active metabolite oxipurinol in elderly and you...

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Autori principali: Turnheim, K, Krivanek, P, Oberbauer, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014375/
https://ncbi.nlm.nih.gov/pubmed/10583019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00041.x
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