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Stereoselective pharmacokinetics of ketoprofen and ketoprofen glucuronide in end-stage renal disease: evidence for a ‘futile cycle’ of elimination

AIMS: To assess if futile cycling of ketoprofen occurs in patients with decreased renal function. METHODS: Ketoprofen was administered to six haemodialysis-dependent patients with end-stage renal disease as single (50 mg) or multiple doses (50 mg three times daily, for 7 days). Plasma and dialysate...

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Detalles Bibliográficos
Main Authors: Grubb, N G, Rudy, D W, Brater, D C, Hall, S D
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 1999
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014373/
https://ncbi.nlm.nih.gov/pubmed/10583018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00046.x
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