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Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man

AIMS: Following intravenous administration of its prodrug, L-758,298, we assessed the pharmacodynamics of L-754,030, a novel and highly selective NK(1) receptor antagonist, by examining systemic haemodynamics and the blood flow responses to intra-arterial substance P infusion. METHODS: Sixteen healt...

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Main Authors: Newby, David E, Sciberras, David G, Ferro, Charles J, Gertz, Barry J, Sommerville, David, Majumdar, Anup, Lowry, Richard C, Webb, David J
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014330/
https://ncbi.nlm.nih.gov/pubmed/10510144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00017.x
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