A comparative analysis of the particle size output of beclomethasone diproprionate, salmeterol xinafoate and fluticasone propionate metered dose inhalers used with the Babyhaler, Volumatic and Aerochamber spacer devices

AIMS: To determine in vitro the effect of delay, inspiratory flow, and spacer washing on the drug output of metered dose inhalers (MDIs) used with different spacer devices. METHODS: The amount of drug in particles <5 μm diameter from MDI+spacer, sampling after a delay of up to 20 s, was measured...

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Autores principales: Barry, P W, O’Callaghan, C
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 1999
Materias:
Drug Delivery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014243/
https://ncbi.nlm.nih.gov/pubmed/10233197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00900.x
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