Characterization of a novel ATP-sensitive K(+) channel opener, A-251179, on urinary bladder relaxation and cystometric parameters

BACKGROUND AND PURPOSE: ATP-sensitive K(+) channels (K(ATP)) play a pivotal role in contractility of urinary bladder smooth muscle. This study reports the characterization of 4-methyl-N-(2,2,2-trichloro-1-(3-pyridin-3-ylthioureido)ethyl)benzamide (A-251179) as a K(ATP) channel opener. EXPERIMENTAL A...

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Détails bibliographiques
Auteurs principaux: Shieh, C-C, Brune, M E, Buckner, S A, Whiteaker, K L, Molinari, E J, Milicic, I A, Fabiyi, A C, Daza, A, Brioni, J D, Carroll, W A, Matsushita, K, Yamada, M, Kurachi, Y, Gopalakrishnan, M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2007
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013963/
https://ncbi.nlm.nih.gov/pubmed/17435796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707249
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