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Irsogladine maleate potentiates the effects of nitric oxide on activation of cAMP signalling pathways and suppression of mesangial cell mitogenesis

BACKGROUND AND PURPOSE: Deficiency in nitric oxide (NO) is a major factor leading to deterioration and progression of certain glomerular diseases. Agents enhancing NO availability and potentiality are renoprotective. Irsogladine maleate (IM), an anti-ulcer drug, is reported to improve gastric blood...

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Main Authors: Yao, J, Zhu, Y, Sun, W, Sawada, N, Hiramatsu, N, Takeda, M, Kitamura, M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013962/
https://ncbi.nlm.nih.gov/pubmed/17435794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707255
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