Choline Transport and de novo Choline Synthesis Support Acetylcholine Biosynthesis in Caenorhabditis elegans Cholinergic Neurons

The cho-1 gene in Caenorhabditis elegans encodes a high-affinity plasma-membrane choline transporter believed to be rate limiting for acetylcholine (ACh) synthesis in cholinergic nerve terminals. We found that CHO-1 is expressed in most, but not all cholinergic neurons in C. elegans. cho-1 null muta...

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Detalhes bibliográficos
Main Authors: Mullen, Gregory P., Mathews, Eleanor A., Vu, Mai H., Hunter, Jerrod W., Frisby, Dennis L., Duke, Angie, Grundahl, Kiely, Osborne, Jamie D., Crowell, John A., Rand, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2007 by the Genetics Society of America 2007
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013710/
https://ncbi.nlm.nih.gov/pubmed/17603106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.074120
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