In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant ΔF508 in murine nasal epithelium

The gene causing cystic fibrosis (CF) encodes the CF transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Mutations in this gene result in reduced transepithelial chloride permeability across tissues affected in CF. Consequently, restoring chloride permeability to these tis...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Kelley, Thomas J., Thomas, Kirk, Milgram, Laura J. H., Drumm, Mitchell L.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1997
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20135/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2604
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