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Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalis

In vitro linezolid resistance was selected at a higher frequency in Enterococcus faecalis JH2-2 than in recombination-deficient E. faecalis UV202. Resistance in JH2-2 was related to accumulated G2576T mutations in 23S rRNA genes, with the least resistance conferred by mutations in two of four copies...

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Bibliografiske detaljer
Main Authors: Lobritz, Michael, Hutton-Thomas, Rebecca, Marshall, Steve, Rice, Louis B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC201147/
https://ncbi.nlm.nih.gov/pubmed/14506047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.10.3318-3320.2003
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