Inhibition of Gene Expression in Escherichia coli by Antisense Phosphorodiamidate Morpholino Oligomers

Antisense phosphorodiamidate morpholino oligomers (PMOs) were tested for the ability to inhibit gene expression in Escherichia coli. PMOs targeted to either a myc-luciferase reporter gene product or 16S rRNA did not inhibit luciferase expression or growth. However, in a strain with defective lipopol...

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Autors principals: Geller, B. L., Deere, J. D., Stein, D. A., Kroeker, A. D., Moulton, H. M., Iversen, P. L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC201127/
https://ncbi.nlm.nih.gov/pubmed/14506035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.10.3233-3239.2003
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