Inhibition of Gene Expression in Escherichia coli by Antisense Phosphorodiamidate Morpholino Oligomers

Antisense phosphorodiamidate morpholino oligomers (PMOs) were tested for the ability to inhibit gene expression in Escherichia coli. PMOs targeted to either a myc-luciferase reporter gene product or 16S rRNA did not inhibit luciferase expression or growth. However, in a strain with defective lipopol...

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Main Authors: Geller, B. L., Deere, J. D., Stein, D. A., Kroeker, A. D., Moulton, H. M., Iversen, P. L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC201127/
https://ncbi.nlm.nih.gov/pubmed/14506035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.10.3233-3239.2003
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