Analysis of Immunological Nonresponsiveness to the 19-Kilodalton Fragment of Merozoite Surface Protein 1 of Plasmodium yoelii: Rescue by Chemical Conjugation to Diphtheria Toxoid (DT) and Enhancement of Immunogenicity by Prior DT Vaccination

The Plasmodium merozoite surface protein 1 (MSP1) is a leading vaccine candidate for protecting against the blood stage of malaria. Previous studies have shown that the 19-kDa carboxyl terminus of this protein is able to induce protective immunity in some monkey and mouse strains. We show that immun...

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Bibliographische Detailangaben
Hauptverfasser: Stanisic, Danielle I., Martin, Laura B., Liu, Xue Q., Jackson, David, Cooper, Juan, Good, Michael F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC201061/
https://ncbi.nlm.nih.gov/pubmed/14500491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.10.5700-5713.2003
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