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Improved Immunogenicity and Efficacy of the Recombinant 19-Kilodalton Merozoite Surface Protein 1 by the Addition of Oligodeoxynucleotide and Aluminum Hydroxide Gel in a Murine Malaria Vaccine Model

Vaccination of mice with yeast-secreted Plasmodium yoelii-derived 19-kilodalton merozoite surface protein 1 (yMSP1(19)) has been shown to afford protection from challenge with a lethal strain of P. yoelii. Sterile immunity can be achieved when MSP1(19) is emulsified in Freund adjuvant but not when i...

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Detalles Bibliográficos
Main Authors: Near, Karen A., Stowers, Anthony W., Jankovic, Dragana, Kaslow, David C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC127724/
https://ncbi.nlm.nih.gov/pubmed/11796601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.2.692-701.2002
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