The antitumour agent 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC) inhibits rat liver cAMP phosphodiesterase and amplifies hormone effects in hepatocytes and hepatoma cells.

The antitumour agent 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) was found to inhibit competitively the low-Km cyclic AMP phosphodiesterase activity in an ammonium-sulphate-precipitable fraction of the 2,000g supernatant of rat liver. With substrate concentration at 0.25 microM, I50 wa...

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Detalhes bibliográficos
Main Authors: Larsson, P. G., Haffner, F., Brłnstad, G. O., Christoffersen, T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1979
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2010101/
https://ncbi.nlm.nih.gov/pubmed/228692
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