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Chloride conductance and genetic background modulate the cystic fibrosis phenotype of ΔF508 homozygous twins and siblings

To investigate the impact of chloride (Cl(–)) permeability, mediated by residual activity of the cystic fibrosis transmembrane conductance regulator (CFTR) or by other Cl(–) channels, on the manifestations of cystic fibrosis (CF), we determined Cl(–) transport properties of the respiratory and intes...

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Udgivet i:J Clin Invest
Principais autores: Bronsveld, Inez, Mekus, Frauke, Bijman, Jan, Ballmann, Manfred, de Jonge, Hugo R., Laabs, Ulrike, Halley, Dicky J., Ellemunter, Helmut, Mastella, Gianni, Thomas, Stephen, Veeze, Henk J., Tümmler, Burkhard
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200980/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11733566/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12108
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