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Establishment of methylation-sensitive–representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors

Methylation of CpG sites in the genome, which is generally conserved during cell replication, is considered to play important roles in cell differentiation and carcinogenesis. However, investigations on changes in methylation status have been limited to known genes. To make a genome-wide search for...

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Bibliografische gegevens
Hoofdauteurs: Ushijima, Toshikazu, Morimura, Keiichirou, Hosoya, Yoko, Okonogi, Hideo, Tatematsu, Masae, Sugimura, Takashi, Nagao, Minako
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences of the USA 1997
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20079/
https://ncbi.nlm.nih.gov/pubmed/9122186
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