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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
Opposing mitochondrial fission and fusion reactions determine the shape and interconnectivity of mitochondria. Dynamin-related protein 1 (Drp1) is an ancient mechanoenzyme that uses GTP hydrolysis to power the constriction and division of mitochondria. Although Drp1-mediated mitochondrial fragmentat...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2002551/ https://ncbi.nlm.nih.gov/pubmed/17721437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401062 |
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