TGF-β is a critical mediator of acute lung injury

We have shown that the integrin αvβ6 activates latent TGF-β in the lungs and skin. We show here that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI). Pharmacologic inhibition of TGF-β also protected wild-type mice from...

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Detalhes bibliográficos
Main Authors: Pittet, Jean-Francois, Griffiths, Mark J.D., Geiser, Tom, Kaminski, Naftali, Dalton, Stephen L., Huang, Xiaozhu, Brown, Lou Anne S., Gotwals, Phillip J., Koteliansky, Victor E., Matthay, Michael A., Sheppard, Dean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC200192/
https://ncbi.nlm.nih.gov/pubmed/11413161
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