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Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis

Decreases in blood pH activate NHE3, the proximal tubular apical membrane Na/H antiporter. In cultured renal epithelial cells, activation of the endothelin-B (ET(B)) receptor increases NHE3 activity. To examine the role of the ET(B) receptor in the response to acidosis in vivo, the present studies e...

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Autori principali: Laghmani, Kamel, Preisig, Patricia A., Moe, Orson W., Yanagisawa, Masashi, Alpern, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC200190/
https://ncbi.nlm.nih.gov/pubmed/11413164
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