The in vitro effects and cross-resistance patterns of some novel anthracyclines.

A range of new anthracyclines, structurally related to adriamycin (ADM), has been synthesised and studied in vitro. Three compounds described in this paper (Ro 31-1215; Ro 31-1741; Ro 31-2035) are all 4-demethoxyanthracyclines. In the mouse mammary tumour cell line, EMT6/Ca/VJAC, using a 1 h drug ex...

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Hauptverfasser: Twentyman, P. R., Fox, N. E., Wright, K. A., Workman, P., Broadhurst, M. J., Martin, J. A., Bleehen, N. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1986
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2001391/
https://ncbi.nlm.nih.gov/pubmed/3459509
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