New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures

BACKGROUND: In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development. We describe a transcriptomic and proteomic analysis of the effects of deletin...

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Main Authors: Hesketh, Andy, Bucca, Giselda, Laing, Emma, Flett, Fiona, Hotchkiss, Graham, Smith, Colin P, Chater, Keith F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000904/
https://ncbi.nlm.nih.gov/pubmed/17678549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-8-261
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