Effects of three cytochrome P450 inhibitors, ketoconazole, fluconazole, and paroxetine, on the pharmacokinetics of lasofoxifene

AIMS: Two studies were conduced to assess the effects of ketoconazole, a CYP3A4/5 inhibitor; fluconazole, a CYP2C9 inhibitor; and paroxetine, a CYP2D6 inhibitor, on lasofoxifene pharmacokinetics. METHODS: The first parallel group study was conducted in 45 healthy postmenopausal women (15 per group)...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ouellet, D, Bramson, C, Roman, D, Remmers, A E, Randinitis, E, Milton, A, Gardner, M
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Blackwell Science Inc 2007
विषय:
Drug Interactions
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000715/
https://ncbi.nlm.nih.gov/pubmed/16822276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02709.x
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