Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics

AIMS: To evaluate the effects of gender, age, diabetes mellitus, renal and hepatic impairment on tadalafil pharmacokinetics and tolerability. METHODS: Six single-dose (5, 10 or 20 mg orally) clinical pharmacology studies were conducted in the UK, Belgium, Poland and Germany in healthy male and femal...

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Main Authors: Forgue, S Thomas, Phillips, Diane L, Bedding, Alun W, Payne, Christopher D, Jewell, Hayley, Patterson, Beverley E, Wrishko, Rebecca E, Mitchell, Malcolm I
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2007
Fag:
Pharmacokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000708/
https://ncbi.nlm.nih.gov/pubmed/16869816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02726.x
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