Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization

The Ig superfamily (IgSF) intercellular adhesion molecule-1 (ICAM-1) equilibrates between monomeric and dimeric forms on the cell surface, and dimerization enhances cell adhesion. A crystal structure of ICAM-1 IgSF domains (D) 3–5 revealed a unique dimerization interface in which D4s of two protomer...

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Bibliographic Details
Main Authors: Chen, Xuehui, Kim, Thomas Doohun, Carman, Christopher V., Mi, Li-Zhi, Song, Gang, Springer, Timothy A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000496/
https://ncbi.nlm.nih.gov/pubmed/17881562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707406104
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