Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons

Cilia regulate diverse functions such as motility, fluid balance, and sensory perception. The cilia of olfactory sensory neurons (OSNs) compartmentalize the signaling proteins necessary for odor detection; however, little is known regarding the mechanisms of protein sorting/entry into olfactory cili...

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Bibliographische Detailangaben
Hauptverfasser: McEwen, Dyke P., Koenekoop, Robert K., Khanna, Hemant, Jenkins, Paul M., Lopez, Irma, Swaroop, Anand, Martens, Jeffrey R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000398/
https://ncbi.nlm.nih.gov/pubmed/17898177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704140104
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