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Sodium–calcium exchange does not require allosteric calcium activation at high cytosolic sodium concentrations
The activity of the cardiac Na(+)–Ca(2+) exchanger (NCX1.1) is allosterically regulated by Ca(2+), which binds to two acidic regions in the cytosolically disposed central hydrophilic domain of the NCX protein. A mutation in one of the regulatory Ca(2+) binding regions (D447V) increases the half-acti...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1995697/ https://ncbi.nlm.nih.gov/pubmed/16809364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.113910 |
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