Sodium–calcium exchange does not require allosteric calcium activation at high cytosolic sodium concentrations

The activity of the cardiac Na(+)–Ca(2+) exchanger (NCX1.1) is allosterically regulated by Ca(2+), which binds to two acidic regions in the cytosolically disposed central hydrophilic domain of the NCX protein. A mutation in one of the regulatory Ca(2+) binding regions (D447V) increases the half-acti...

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Bibliografiske detaljer
Main Authors: Urbanczyk, Jason, Chernysh, Olga, Condrescu, Madalina, Reeves, John P
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2006
Fag:
Cellular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995697/
https://ncbi.nlm.nih.gov/pubmed/16809364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.113910
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