A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

Osteoporosis is a common disease with a strong genetic component. We previously described a polymorphic Sp1 binding site in the COL1A1 gene that has been associated with osteoporosis in several populations. Here we explore the molecular mechanisms underlying this association. A meta-analysis showed...

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Huvudupphovsmän: Mann, Val, Hobson, Emma E., Li, Baohua, Stewart, Tracy L., Grant, Struan F.A., Robins, Simon P., Aspden, Richard M., Ralston, Stuart H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2001
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC199568/
https://ncbi.nlm.nih.gov/pubmed/11285309
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