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Discordant effects of anti–VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis

Initial migration of encephalitogenic T cells to the central nervous system (CNS) in relapsing experimental autoimmune encephalomyelitis (R-EAE), an animal model of multiple sclerosis (MS), depends on the interaction of the α4 integrin (VLA-4) expressed on activated T cells with VCAM-1 expressed on...

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Main Authors: Theien, Bradley E., Vanderlugt, Carol L., Eagar, Todd N., Nickerson-Nutter, Cheryl, Nazareno, Remederios, Kuchroo, Vijay K., Miller, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC199558/
https://ncbi.nlm.nih.gov/pubmed/11306603
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