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Spectrum of disease-causing mutations in protein secondary structures

BACKGROUND: Most genetic disorders are linked to missense mutations as even minor changes in the size or properties of an amino acid can alter or prevent the function of the protein. Further, the effect of a mutation is also dependent on the sequence and structure context of the alteration. RESULTS:...

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Autors principals: Khan, Sofia, Vihinen, Mauno
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995201/
https://ncbi.nlm.nih.gov/pubmed/17727703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-56
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