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Why targeted therapy hasn’t worked in advanced cancer
In this issue of the JCI, Nissen et al. report that a reciprocal interaction exists between the growth factors FGF2 and PDGF-BB, causing tumors to exhibit increased angiogenesis and metastatic potential (see the related article beginning on page 2766). Both FGF2 and PDGF-BB signal through tyrosine k...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2007
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1994633/ https://ncbi.nlm.nih.gov/pubmed/17909624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33190 |
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