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Activation of the murine EP3 receptor for PGE(2) inhibits cAMP production and promotes platelet aggregation

The importance of arachidonic acid metabolites (termed eicosanoids), particularly those derived from the COX-1 and COX-2 pathways (termed prostanoids), in platelet homeostasis has long been recognized. Thromboxane is a potent agonist, whereas prostacyclin is an inhibitor of platelet aggregation. In...

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Udgivet i:J Clin Invest
Principais autores: Fabre, Jean-Etienne, Nguyen, MyTrang, Athirakul, Krairek, Coggins, Kenneth, McNeish, John D., Austin, Sandra, Parise, Leslie K., FitzGerald, Garret A., Coffman, Thomas M., Koller, Beverly H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199422/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238561/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10881
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