Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase

Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS(−/−)) and...

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Main Authors: Szabó, Csaba, Virág, László, Cuzzocrea, Salvatore, Scott, Gwen S., Hake, Paul, O’Connor, Michael P., Zingarelli, Basilia, Salzman, Andrew, Kun, Ernest
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC19929/
https://ncbi.nlm.nih.gov/pubmed/9520459
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