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Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapy

To initiate infection, HIV-1 requires a primary receptor, CD4, and a secondary receptor, principally the chemokine receptor CCR5 or CXCR4. Coreceptor usage plays a critical role in HIV-1 disease progression. HIV-1 transmitted in vivo generally uses CCR5 (R5), but later CXCR4 (X4) strains may emerge;...

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Publicado no:J Clin Invest
Principais autores: Philpott, Sean, Weiser, Barbara, Anastos, Kathryn, Kitchen, Christina Michelle Ramirez, Robison, Esther, Meyer, William A., Sacks, Henry S., Mathur-Wagh, Usha, Brunner, Cheryl, Burger, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199259/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11181642/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11526
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