The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance

After receiving lamivudine for 3 years to treat chronic hepatitis B, 67–75% of patients develop B-domain L528M, C-domain M552I, or M552V mutations in the HBV polymerase that render hepatitis B virus (HBV) drug-resistant. The aim of this study was to evaluate the influence of these mutations on viral...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Ono, Suzane Kioko, Kato, Naoya, Shiratori, Yasushi, Kato, Jun, Goto, Tadashi, Schinazi, Raymond F., Carrilho, Flair José, Omata, Masao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11181644/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11100
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