Antibody-mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy

CD45 is a family of transmembrane protein tyrosine phosphatases exclusively expressed by hematopoietic cells and critically involved in the regulation of T cell activation signals. We now demonstrate that three 100-μg doses of anti-CD45RB mAb MB23G2 can induce long-term engraftment of islets into ma...

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Detalhes bibliográficos
Main Authors: Basadonna, G. P., Auersvald, L., Khuong, C. Q., Zheng, X. X., Kashio, N., Zekzer, D., Minozzo, M., Qian, H.-Y., Visser, L., Diepstra, A., Lazarovits, A. I., Poppema, S., Strom, T. B., Rothstein, D. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19921/
https://ncbi.nlm.nih.gov/pubmed/9520451
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