Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women

The placenta may play a critical role in inhibiting vertical transmission of HIV-1. Here we demonstrate that leukemia inhibitory factor (LIF) is a potent endogenous HIV-1–suppressive factor produced locally in placentae. In vitro, LIF exerted a potent, gp130-LIFRβ–dependent, HIV coreceptor–independe...

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Hauptverfasser: Patterson, Bruce K., Behbahani, Homira, Kabat, William J., Sullivan, Yvonne, O’Gorman, Maurice R.G., Landay, Alan, Flener, Zareefa, Khan, Nadia, Yogev, Ram, Andersson, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC199198/
https://ncbi.nlm.nih.gov/pubmed/11160152
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