Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

Several lines of investigation suggest that the hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates body weight in mammals. Obese mice lacking functional leptin overexpress the MCH message in the fed or fasted state. Acute intracerebroventricular injection of MCH increases energy...

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Main Authors: Ludwig, David S., Tritos, Nicholas A., Mastaitis, Jason W., Kulkarni, Rohit, Kokkotou, Efi, Elmquist, Joel, Lowell, Bradford, Flier, Jeffrey S., Maratos-Flier, Eleftheria
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC199192/
https://ncbi.nlm.nih.gov/pubmed/11160162
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