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Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5

Adeno-associated virus serotype 5 (AAV5) is under development for gene-therapy applications for the treatment of cystic fibrosis. To elucidate the structural features of AAV5 that control its enhanced transduction of the apical surface of airway epithelia compared with other AAV serotypes, X-ray cry...

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Autors principals: DiMattia, Michael, Govindasamy, Lakshmanan, Levy, Hazel C., Gurda-Whitaker, Brittney, Kalina, Amy, Kohlbrenner, Erik, Chiorini, John A., McKenna, Robert, Muzyczka, Nicholas, Zolotukhin, Sergei, Agbandje-McKenna, Mavis
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1991325/
https://ncbi.nlm.nih.gov/pubmed/16511195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309105028514
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