Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5

Adeno-associated virus serotype 5 (AAV5) is under development for gene-therapy applications for the treatment of cystic fibrosis. To elucidate the structural features of AAV5 that control its enhanced transduction of the apical surface of airway epithelia compared with other AAV serotypes, X-ray cry...

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Bibliographic Details
Main Authors: DiMattia, Michael, Govindasamy, Lakshmanan, Levy, Hazel C., Gurda-Whitaker, Brittney, Kalina, Amy, Kohlbrenner, Erik, Chiorini, John A., McKenna, Robert, Muzyczka, Nicholas, Zolotukhin, Sergei, Agbandje-McKenna, Mavis
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2005
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1991325/
https://ncbi.nlm.nih.gov/pubmed/16511195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309105028514
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