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Role of MGMT in Protecting against Cyclophosphamide-Induced Toxicity in Cells and Animals
O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that protects cells from the biological consequences of alkylating agents by removing alkyl groups from the O(6)-position of guanine. Cyclophosphamide and ifosfamide are oxazaphosphorines used clinically to treat a wide variety...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1989758/ https://ncbi.nlm.nih.gov/pubmed/17485251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.03.010 |
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