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Ultratrace liquid chromatography/mass spectrometry analysis of large peptides with post-translational modifications using narrow-bore poly(styrene-divinylbenzene) monolithic columns and extended range proteomic analysis

This paper describes approaches to optimize the chromatographic performance for our recently developed LC-MS platform, extended range proteomic analysis (ERPA), for comprehensive protein characterization at the ultratrace level. Large digested peptide fragments up to 10 kDa (e.g. from lysyl endopept...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Jian, Wu, Shiaw-Lin, Kim, Jeongkwon, Karger, Barry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1989678/
https://ncbi.nlm.nih.gov/pubmed/17442327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2007.03.128
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