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Failure of drugs that selectively inhibit thromboxane synthesis to modify endotoxin shock in conscious rats.

The effects of two thromboxane synthetase inhibitors ( dazoxiben and UK 38485) were investigated on the cardiovascular and metabolic effects of Escherichia coli endotoxin infusion in the conscious, unrestrained rat. Infusion of E. coli endotoxin (41.7 ng kg-1 min-1) for 4 h produced a fall in mean a...

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Autori principali: Furman, B. L., McKechnie, K., Parratt, J. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1984
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987265/
https://ncbi.nlm.nih.gov/pubmed/6375795
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