Non-specific, time-dependent desensitization of the vas deferens and anococcygeus preparations of the rat to alpha 1-adrenoceptor antagonists and atropine.

Rat vas deferens preparations became desensitized to the alpha 1-adrenoceptor antagonist thymoxamine: after 6 h in vitro, the t 1/2 value (time to attain half the occupancy of receptors occupied at equilibrium) of the response to this drug was 1.50 fold greater in control strips (strips exposed to t...

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Bibliographic Details
Main Author: Onnen, I.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1984
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987162/
https://ncbi.nlm.nih.gov/pubmed/6148980
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