2-Alkyl analogue of idazoxan (RX 781094) with enhanced antagonist potency and selectivity at central alpha 2-adrenoceptors in the rat.

Four 2-alkyl (methyl, ethyl, n-propyl and isopropenyl) analogues of idazoxan (RX 781094) have been synthesized and assessed in terms of their central alpha 2/alpha 1-adrenoceptor selectivity and alpha 2-adrenoceptor antagonist potency using both in vitro and in vivo tests in the rat. In cortical bin...

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Hlavní autoři: Gadie, B., Lane, A. C., McCarthy, P. S., Tulloch, I. F., Walter, D. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1984
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987074/
https://ncbi.nlm.nih.gov/pubmed/6150739
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