The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene.

Intra-arterial injections of platelet-activating factor (Paf-acether, 10-300 ng) to the perfused guinea-pig lung induced a dose-related bronchoconstriction, followed by contraction of the rat aorta superfused with the lung effluent, indicating the release of thromboxane A2 (TXA2) activity. These eff...

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Bibliographic Details
Main Authors: Lefort, J., Rotilio, D., Vargaftig, B. B.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1984
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987001/
https://ncbi.nlm.nih.gov/pubmed/6430375
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